Isixazululo somdlavuza we-endometrial, ukuqeda umdlavuza esigabeni sezilonda ze-precancerous.Umdlavuza we-Endometrial ungomunye wemidlavuza emithathu emikhulu eyingozi ku-gynecology.
Umdlavuza we-Endometrial ungomunye wemidlavuza eyingozi evamile ohlelweni lokuzala kwabesifazane, ukleliswe endaweni yesibili phakathi kwezifo ezimbi zesistimu yokuzala yabesifazane eShayina, futhi uvame kakhulu kwabesifazane basemadolobheni.Ngokwezibalo ze-International Agency for Research on Cancer yeWorld Health Organisation, cishe kube nezigameko ezintsha ezingama-420,000 zomdlavuza we-endometrial emhlabeni wonke ngo-2020, nokufa kwabantu ababalelwa ku-100,000.
Kulezi zimo, cishe izigameko ezintsha ezingama-82,000 zomdlavuza we-endometrial zabikwa eChina, nokufa kwabantu ababalelwa ku-16,000.Kulinganiselwa ukuthi ngo-2035, kuzoba namacala amasha angama-93,000 omdlavuza we-endometrial eChina.
Izinga lokwelapha umdlavuza we-endometrial wesigaba sokuqala liphezulu kakhulu, futhi izinga lokusinda leminyaka emi-5 lifinyelela kuma-95%.Kodwa-ke, izinga lokusinda leminyaka emi-5 lomdlavuza we-endometrial wesigaba IV liyi-19% kuphela.
Umdlavuza we-Endometrial uvame kakhulu kwabesifazane be-postmenopausal kanye ne-perimenopausal, ngeminyaka yokuqala ephakathi kweminyaka engama-55.Kodwa-ke, eminyakeni yamuva nje, kuye kwaba nokuthambekela okwandayo kwezehlakalo zomdlavuza we-endometrial phakathi kwabesifazane abaneminyaka engama-40 nangaphansi.
Okwamanje ayikho indlela efanele yokuhlola umdlavuza we-endometrial
Kwabesifazane abaneminyaka yobudala yokuzala, ukuhlolwa kusenesikhathi kanye nokuphathwa ngesikhathi komdlavuza we-endometrial kungakhulisa ukulondolozwa kokuzala futhi kunikeze ithuba lokuphila isikhathi eside.
Kodwa-ke, okwamanje azikho izindlela ezibucayi nezinembile zokuhlola umdlavuza we-endometrial ekusebenzeni komtholampilo.Izimpawu ezinjengokopha okungajwayelekile kwesitho sangasese sowesifazane kanye nokuphuma kwesitho sangasese sowesifazane ezigabeni zokuqala azinakwa kalula, okuholela ethubeni eliphuthelwe lokuxilongwa kusenesikhathi.
Ukuhlolwa kokuqala kusetshenziswa imaging ye-ultrasound kanye nokuhlolwa kwezifo zabesifazane okujwayelekile kunokuzwela okuphansi.
Ukusetshenziswa kwe-hysteroscopy kanye ne-pathological biopsy kuhlasela, nge-anesthesia ephezulu kanye nezindleko, futhi kungase kubangele ukopha, ukutheleleka, nokubhobozwa kwesibeletho, okuholela ezingeni eliphezulu lokuxilongwa okuphuthelwe, futhi akusetshenzisiwe njengendlela yokuhlola evamile.
Isampula ye-Endometrial biopsy ingase ibangele ukungakhululeki, ukopha, ukutheleleka, nokubhobozwa kwesibeletho, okuholela ezingeni eliphezulu lokuxilongwa okugejiwe.
I-TAGMe DNA Methylation Detection Kits (qPCR) ye-Endometrial CancerYethula Inkathi Yokuxilonga Umdlavuza We-Endometrial Nokwelashwa 2.0
I-TAGMe DNA Methylation Detection Kits (qPCR) ye-Endometrial Canceringagcwalisa ngempumelelo ukushiyeka kwezindlela ezijwayelekile zokuhlola umdlavuza we-endometrial, inciphise kakhulu izinga lokuxilongwa okugejiwe futhi isize iziguli ukuthi zithole izimpawu zomdlavuza ngesikhathi.
Ukuhlola okungaboni kabili "kuyizinga legolide" lokuqinisekiswa kwezobuchwepheshe kanye nezinga lomtholampilo i-Epiprobe ehlale inamathela kulo!
Imiphumela yokuhlolwa kwe-double blind-blind ibonise ukuthi kumasampuli okuklwebheka komlomo wesibeletho, i-AUC yayingu-0.86, ukucaciswa kwakungu-82.81%, nokuzwela kwaba ngu-80.65%;kumasampula ebhulashi lomgodi wesibeletho, i-AUC yayingu-0.83, ukucaciswa kwakungama-95.31%, nokuzwela kwaba ngu-61.29%.
Emikhiqizweni yokuhlola umdlavuza kusenesikhathi, inhloso eyinhloko ukuhlola abantu abangase babe nenkinga esikhundleni sokuthola ukuxilongwa okuqinisekile.
Ngemikhiqizo yokuhlola umdlavuza kusenesikhathi, uma kucatshangelwa ukuthi inhloso yokusetshenziswa komsebenzisi ukuqeda ubungozi bokugula kanye nokugwema ukuxilonga okugejiwe ngangokunokwenzeka kuwubuqotho obukhulu kakhulu kubantu abahloliwe.
Inani lokubikezela elingalungile leI-TAGMe DNA Methylation Detection Kits (qPCR) ye-Endometrial Canceringu-99.4%, okusho ukuthi kubantu abathola imiphumela engemihle, u-99.4% wemiphumela engemihle uyimibi yangempela.Ikhono lokuvimbela ukuxilonga okugejiwe livelele kakhulu, futhi iningi labasebenzisi abangalungile lingaqiniseka ukuthi abadingi ukuhlolwa okuhlaselayo okunamazinga aphezulu okuxilongwa aphuthelwe.Lesi isivikelo esikhulu kakhulu sabasebenzisi.
Ukuzihlola ngokwakho izici eziyingozi zomdlavuza we-endometrial.
Ngokuthuthuka kwamazinga okuphila, izigameko zomdlavuza we-endometrial eShayina bezilokhu zanda unyaka nonyaka, futhi kukhona ukuthambekela ezigulini ezisencane.
Ngakho-ke, hlobo luni lwabantu olungase lube nomdlavuza we-endometrial?
Ngokuvamile, abantu okungenzeka babe nomdlavuza we-endometrial banezici eziyisithupha ezilandelayo:
- Uhlushwa yi-metabolic syndrome: isifo esibonakala ngokukhuluphala, ikakhulukazi ukukhuluphala kwesisu, kanye noshukela ophezulu wegazi, ama-lipids egazi angavamile, umfutho wegazi ophakeme, njll., esithinta kakhulu impilo yomzimba;
- Ukukhuthazwa kwe-estrogen eyodwa yesikhathi eside: ukuchayeka isikhathi eside ekugqugquzelweni kwe-estrogen eyodwa ngaphandle kweprogesterone ehambisanayo ukuvikela i-endometrium;
- Ukuqala kokuya esikhathini kanye nokunqamuka kokuya esikhathini sekwephuzile: lokhu kusho ukuthi inani lemijikelezo yokuya esikhathini liyakhula, ngakho-ke i-endometrium ibhekene nokugqugquzelwa kwe-estrogen isikhathi eside;
- Ukungazali izingane: ngesikhathi sokukhulelwa, izinga le-progesterone emzimbeni liphezulu, elingavikela i-endometrium;
- Izici zofuzo: eyohlobo lwakudala kakhulu i-Lynch syndrome.Uma kunezimo ezincane zomdlavuza we-colorectal, umdlavuza wesisu, noma izihlobo zesifazane ezinomdlavuza we-ovarian, umdlavuza we-endometrial, njll phakathi kwezihlobo eziseduze, kufanele kuqashelwe futhi ukwelulekwa ngofuzo nokuhlolwa kungenziwa;
- Imikhuba yempilo engalungile: njengokubhema, ukungazivocavoci, nokuthanda ukudla okunekhalori ephezulu nokudla okunamafutha amaningi okufana namashibhisi amazambane, ama-french, itiye lobisi, ukudla okuthosiwe, amakhekhe kashokoledi, njll., ngakho-ke kuyadingeka ukuzivocavoca. ngaphezulu ngemva kokuwadla.
Ungaziqhathanisa nezici ezingu-6 ezingenhla okungenzeka zibe nomdlavuza we-endometrial, futhi uzame ukuzilungisa ngangokunokwenzeka ukuze uwuvimbele emthonjeni.
Isikhathi sokuthumela: May-09-2023